Accutane Side Effects: Should Depression Be A Concern?

Medical professionals and acne-pestered adolescents have no doubts about the effectiveness of the severe acne drug isotretinoin. It?s the looming possibility of side effects such as depression and fetal damage that makes people uneasy when considering using this medication.

Accutane (isotretinoin) is one of Hoffman-LaRoche?s most popular and controversial pharmaceuticals. This week, a study published in the Archives of Dermatology vindicated isotretinoin from causing depression. In this report, Christina Y. Chia, MD, from Saint Louis University Health Sciences Center, St. Louis, and colleagues examined whether patients with moderate to severe acne treated with isotretinoin experienced an increase in depressive symptoms compared with patients treated with a topical antibiotic, topical retinoid, and an oral antibiotic.

Dr. Chia found that ?The use of isotretinoin in the treatment of moderate-severe acne in adolescents did not increase depressive symptoms. On the contrary, our study shows that treatment of acne improves depressive symptoms?.

Five years earlier, in 2000, the isotretinoin-depression link still appeared misleading. That time, the Archives of Dermatology posted study, headed by Dr. Susan S. Jick, from the Boston University School of Medicine, which found no evidence that isotretinoin increases the risk for depression, suicide, or other psychiatric disorders.

Even though isotretinoin finds ample support among dermatologists and psychiatrists, a host of parents, politicians and medical professionals hail isotretinoin as a medical misfortune. For instance, Dr. David J. Graham, the Associate Director for Science and Medicine in FDA?s Office of Drug Safety, recently warned that Accutane should be taken off the market.

And while there are few studies with any negative observations about isotretinoin, Dr. Douglas Bremner?s research at of the Emory University School of Medicine has linked isotretinoin treatment with changes in brain function. At the conclusion of this study, published in the American Journal of Psychiatry, Dr. Bremner concurred with Dr. Graham?s view that isotretinoin proves too dangerous for human use.

Dr. Bremner explains that to invoke depression, isotretinoin must influence the brain. During the investigation, brain function of the subjects was measured using positron emission tomography (PET) before and after four months of treatment with isotretinoin. Isotretinoin treatment was associated with decreased brain metabolism in the orbitofrontal cortex- the area of the brain known to mediate symptoms of depression. Yet, there were no differences in severity of depressive symptoms between the isotretinoin and antibiotic treatment groups before or after treatment.

The pessimistic effects of isotretinoin also caught the attention of Diane K. Wysowski PhD. Dr. Wysowski noted that in June 2000, isotretinoin ranked among the top 10 drugs linked to depression and suicide attempts in the FDA's Adverse Event Reporting System database. In 2001, Dr. Wysowski examined isotretinoin?s depression inducing potential and posted her findings in the Journal of the American Academy of Dermatology.

Dr. Wysowski concluded that more studies of isotretinoin are needed. She also advised patients and their parents to immediately report mood swings and symptoms that are suggestive of depression such as sadness, crying, loss of appetite, unusual fatigue, withdrawal, and inability to concentrate to their prescribing physician. These protective measures can avoid more serious side effects and permit appropriate treatment, including consideration of drug discontinuation and referral for psychiatric care.

While dissension among researchers still exists about whether or not isotretinoin causes depression, one idea most of them can agree on is that more research on the side effects of isotretinoin are desirable. If you are not in the mood for being an isotretinoin guinea pig, Geoffrey Redmond MD, author of The Good News about Women?s Hormones, suggests using hormone therapy and/or using Retin-A if isotretinoin seems too chancy for you.

Health author and Stanford University graduate Naweko San-Joyz lovingly writes from her home in San Diego. Her works include ?Acne Messages: Crack the code of your zits and say goodbye to acne? (ISBN: 0974912204) and the upcoming work ?Skinny Fat Chicks, Why we?re still not getting this dieting thing? (ISBN: 0974912212) for release in June of 2005. For useful acne self-help articles visit http://www.Noixia.com

An Acne Fetish is No Laughing Matter

While it may be easy to scoff off an acne fetish with remarks like, ?I don?t have that problem,? this condition is more common than properly acknowledged. A fetish is an object of unreasonably obsessive attention or regard. Thus, extreme attention given to zits and pimples characterize an acne fetish. Two clinical forms of an acne fetish include excoriated acne and imagined acne.

Excoriated acne occurs when an acne patient continues to pick at or squeeze acne formations on their face, never allowing the skin to heal. This constant picking aggravates the acne condition and often times leaves severe scarring. Imagined acne happens when a patient is convinced she has acne but in reality does not. This person may have one small pimple and blow the existence of the pimple out of proportion and view it as a severe case of acne.

Underlying both of these acne fetishes is the fear of being ugly, or dysmorphophobia. It?s an easy psychological state to acquire in a society that increasingly places more value on superficial looks than personal traits.

Steps to combating an acne fetish include: Spending less time self-critiquing in front of the mirror; and Embellishing your talents.

Even a hiatus from mirror visits may help an acne fetish. If you do look in the mirror, focus on elements of your face besides the zits. For instance, look at the color of your eyes or the size of your lips, without criticizing of course. You may have lovely eyelashes or the perfect eyebrows. Whenever you look in the mirror stop making negative judgments about yourself. If you do find yourself ridiculing yourself and wanting to burst a zit in a rushed desire for clear skin, just remind yourself that every zit that you prematurely pop may encourage the formation of 3 completely new zits.

Focus on your greatest assets as a person, or cultivate new skills. You may be an awesome guitar player or fabulous singer, give yourself recognition for your strengths. Do something that you?ve always wanted to do, but did not do because you felt having acne precludes you from this activity.

In the final analysis, healing an acne fetish starts with recognizing that this condition has serious medical repercussions. An acne fetish can debilitate one?s self-esteem while encouraging needless facial scarring. If you think you have an acne fetish, you can get help from a qualified dermatologist, psychologists or just talk it over with some really cool and understanding friends.

Naweko San-Joyz is creator of the Acne Messages program, the only acne program to combine the latest scientific research and ancient wisdom to deliver an acne cure as unique as the acne sufferer. As there are millions of people with acne, there are a millions cures, find your unique cure with Acne Messages. ISBN: 0974912204 available at Amazon and Noixia.com, Home of Six Billion Natural Cures for Acne

Accutane Side Effects: Should Depression Be A Concern?

Medical professionals and acne-pestered adolescents have no doubts about the effectiveness of the severe acne drug isotretinoin. It?s the looming possibility of side effects such as depression and fetal damage that makes people uneasy when considering using this medication.

Accutane (isotretinoin) is one of Hoffman-LaRoche?s most popular and controversial pharmaceuticals. This week, a study published in the Archives of Dermatology vindicated isotretinoin from causing depression. In this report, Christina Y. Chia, MD, from Saint Louis University Health Sciences Center, St. Louis, and colleagues examined whether patients with moderate to severe acne treated with isotretinoin experienced an increase in depressive symptoms compared with patients treated with a topical antibiotic, topical retinoid, and an oral antibiotic.

Dr. Chia found that ?The use of isotretinoin in the treatment of moderate-severe acne in adolescents did not increase depressive symptoms. On the contrary, our study shows that treatment of acne improves depressive symptoms?.

Five years earlier, in 2000, the isotretinoin-depression link still appeared misleading. That time, the Archives of Dermatology posted study, headed by Dr. Susan S. Jick, from the Boston University School of Medicine, which found no evidence that isotretinoin increases the risk for depression, suicide, or other psychiatric disorders.

Even though isotretinoin finds ample support among dermatologists and psychiatrists, a host of parents, politicians and medical professionals hail isotretinoin as a medical misfortune. For instance, Dr. David J. Graham, the Associate Director for Science and Medicine in FDA?s Office of Drug Safety, recently warned that Accutane should be taken off the market.

And while there are few studies with any negative observations about isotretinoin, Dr. Douglas Bremner?s research at of the Emory University School of Medicine has linked isotretinoin treatment with changes in brain function. At the conclusion of this study, published in the American Journal of Psychiatry, Dr. Bremner concurred with Dr. Graham?s view that isotretinoin proves too dangerous for human use.

Dr. Bremner explains that to invoke depression, isotretinoin must influence the brain. During the investigation, brain function of the subjects was measured using positron emission tomography (PET) before and after four months of treatment with isotretinoin. Isotretinoin treatment was associated with decreased brain metabolism in the orbitofrontal cortex- the area of the brain known to mediate symptoms of depression. Yet, there were no differences in severity of depressive symptoms between the isotretinoin and antibiotic treatment groups before or after treatment.

The pessimistic effects of isotretinoin also caught the attention of Diane K. Wysowski PhD. Dr. Wysowski noted that in June 2000, isotretinoin ranked among the top 10 drugs linked to depression and suicide attempts in the FDA's Adverse Event Reporting System database. In 2001, Dr. Wysowski examined isotretinoin?s depression inducing potential and posted her findings in the Journal of the American Academy of Dermatology.

Dr. Wysowski concluded that more studies of isotretinoin are needed. She also advised patients and their parents to immediately report mood swings and symptoms that are suggestive of depression such as sadness, crying, loss of appetite, unusual fatigue, withdrawal, and inability to concentrate to their prescribing physician. These protective measures can avoid more serious side effects and permit appropriate treatment, including consideration of drug discontinuation and referral for psychiatric care.

While dissension among researchers still exists about whether or not isotretinoin causes depression, one idea most of them can agree on is that more research on the side effects of isotretinoin are desirable. If you are not in the mood for being an isotretinoin guinea pig, Geoffrey Redmond MD, author of The Good News about Women?s Hormones, suggests using hormone therapy and/or using Retin-A if isotretinoin seems too chancy for you.

Health author and Stanford University graduate Naweko San-Joyz lovingly writes from her home in San Diego. Her works include ?Acne Messages: Crack the code of your zits and say goodbye to acne? (ISBN: 0974912204) and the upcoming work ?Skinny Fat Chicks, Why we?re still not getting this dieting thing? (ISBN: 0974912212) for release in June of 2005. For useful acne self-help articles visit http://www.Noixia.com